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In complicated infections, that shows the path is
Product Name: CETREX
Injections
Ceftriaxone 125/250/500 mg , 1 & 2 gm injections
Offers commanding effect in chloramphenicolresistant H. influenzae infection Well-documented in typhoidal and non-typhoidal salmonellosis Highly beneficial for prophylaxis in urological surgery Extends better compliance than penicillin G
"Using a third generation cephalosporin as first line treatment is effective in dealing with the problem of poor outcomes from meningitis due to Haemophilus influenzae that is resistant to chloramphenicol." High C-reactive protein (CRP), prolonged high fever and signs of moderate or severe dehydration appear appropriate to define severe cases of Salmonella enterocolitis. Short-course ceftriaxone therapy is clinically beneficial to these patients. Neither clinical nor microbiological relapse was seen after therapy. " In selected patients undergoing nephrectomy and requiring antimicrobial prophylaxis such as manourished, debilitated, diabetic or immunosuppressed patients, the use of a single dose of ceftriaxone (1000 mg) makes it possible to offer an optimal bacterial coverage for the prevention of postoperative infection. According to our kinetic evaluation, ceftriaxone is potentially a good antibiotic for prophylaxis in urological surgery." Ceftriaxone and sodium penicillin G were equally effective for the treatment of severe leptospirosis. Once-daily administration and the extended spectrum of ceftriaxone against bacteria provide additional benefits over intravenous penicilin.
Indications: - Nosocomial infections - Sexually transmitted diseases - Typhoid - Skin and soft tissue infections - Acute otitis media
Medical Jr. Duke T et al., Arch Dis Child. 2003 Jun;88(6): 536-9 Lin TY et al., Acta Paediatr. 2003 May;92(5): 537-40 Leone M et al., J Chemother. 2003 Apr; 15(2): 1939-42 Panaphut T et al., Clin Infect Dis. 2003 Jun 15; 36(12): 1507-13