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| Even the sky is not a limit |
| Product Name: |
| Tablets/Syrup/Injection |
| Promethazine |
| Prozine 10/25 tablet(Promethazine 10/25 mg) , Prozine Syrup(Promethazine 5mg/ml 60ml & 100ml bottle), Prozine Inj.(Promethazine 25mg/ml 2ml Ampoule |
| The antihistamine that reached to space |
| Exhibits additive effect with ondansetron |
| Produces additional anti-inflammatory effect |
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| "We evaluated in-flight use of medications from astronaut debriefings after 79 U.S. Space shuttle missions. Promethazine, the only drug given by three different routes(orally,intramuscularly & rectally) was most effective and had minimal side effects when taken intramuscularly."
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| "The prophylactic of an antiemetic with middle ear surgery may reduce postoperative nausea and vomiting over 24 hours, and the ondansetron/promethazine combination or promethazine alone are cost-effective choices. Finally, the combination reduced significantly the severity of vomiting."
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| "In vitro studies have shown that H1-antihistamines reduce the release of proinflammatory mediators from mast cells and basophils, the chemotaxis and activation of inflammatory cells(especially eosinophils), and the expression of adhesion molecules induced by immunological and nonimmunological stimuli in epithelial cell lines."
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| Indications:
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| Post-operative nausea and vomiting
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| Selective deactivating effects as preanaesthetic medication
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| Steroid-induced psychosis in paediatric patients
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| Prophylaxis and treatment of motion sickness - Obstetric sedative
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| Hypersensitivity reactions
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| Intravenous with meperidine or other narcotics in special surgical procedures as bronchoscopy, ophthalmic surgery, or in poor-risk patients
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Medical Jr.
| Putcha L et al., Aviat Space Environ Med. 1999 Jul; 70(7):705-8
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| Khalil S et al., : J Clin Anesth. 1999 Nov;11(7): 596-600
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| Assanasen P, Naclerio RM. Clin Allergy Immunol. 2002;17:101-39
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